The frequency of interleukin-10 (IL-10) polymorphisms in patients with peptic ulcer and chronic gastritis

ABSTRACT Introduction: Peptic ulcer is a common problem in medicine with serious impacts on the quality of life of patients. It has been shown that Helicobacter pylori infection is related with inflammatory responses of gastric mucosa. However, some patients remain asymptomatic. Sustained colonization and chronic inflammation increase the risk of gastritis and peptic ulcer. The aim of this study is to investigate the genetic polymorphisms of inflammatory cytokine IL-10 and its relationship with peptic ulcer and gastric inflammation. Correspondence: Mohammad Shekari, MD, PhD. Molecular Medicine Research Center, Hormozgan University of Medical Sciences. Bandar Abbas, Iran Tel:+98 76 33354939 Email: [email protected] Methods: In this study, 107 people with symptoms of stomach pain and indigestion referred to a doctor with an indication for endoscopy were selected as the patient group. 107 healthy people without complications such as stomach pain and indigestion were selected as the control group. IL-10-592A/C polymorphism was examined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: No significant difference was found between the patients with peptic ulcer and chronic inflammation and healthy people in the control group in terms of the C allele in the IL-10 gene (P=0.99; 0.48-1.80, CI 95%, OR 0.93, and P=0.26; 0.57-1.13, CI 95%, OR 0.81, respectively). Conclusion: The results showed no significant correlation between the inflammatory cytokine IL-10 gene polymorphisms and peptic ulcer disease and chronic inflammation.